A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10880
Swiss-prot Accession numberP01315 (Sequence in FASTA format)
DescriptionInsulin precursor [Contains: Insulin B chain; Insulin A chain].
Source organismSus scrofa (Pig)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the insulin family.
Tissue SpecificityN/A
Post translational modification N/A
Function Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Protein Length108 Amino acids
Molecular weight11672
References1   Han X.G., Tuch B.E.; "Complete porcine preproinsulin cDNA sequence."; Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
2  PubMed abstract 12140686
3  PubMed abstract 14574411
4  PubMed abstract 5657063
5   Chance R.E.; Submitted (JUL-1970) to the PIR data bank.
6   Blundell T.L., Dodson G.G., Hodgkin D., Mercola D.; "Insulin. The structure in the crystal and its reflection in chemistryand biology."; Adv. Protein Chem. 26:279-402(1972).
7   Isaacs N.W., Agarwal R.C.; "Experience with fast Fourier least squares in the refinement of thecrystal structure of rhombohedral 2-zinc insulin at 1.5-Aresolution."; Acta Crystallogr. A 34:782-791(1978).
8  PubMed abstract 2905485
9  PubMed abstract 1772633
10  PubMed abstract 2025410
11  PubMed abstract 15299880
Domain NameInsulin  
Hormone NameInsulin A chain
Mature Hormone SequenceGIVEQCCTSICSLYQLENYCN
Position of mature hormone in Pre-Hormone protein21 Residues from position (88-108)
ReceptorN/A
Gene ID397415      
PDB ID1B17   1B18   1B19   1B2A   1B2B   1B2C   1B2D   1B2E   1B2F   1B2G   1DEI   1IZA   1IZB   1M5A   1MPJ   1SDB   1WAV   1ZEI   1ZNI   2EFA   2G4M   2TCI   3INS   3MTH   4INS   6INS   7INS   9INS      
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated