A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10870 |
| Swiss-prot Accession number | P04667 (Sequence in FASTA format) |
| Description | Insulin precursor [Contains: Insulin B chain; Insulin A chain]. |
| Source organism | Oncorhynchus keta (Chum salmon) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Euteleostei;Protacanthopterygii; Salmoniformes; Salmonidae; Oncorhynchus. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the insulin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver |
| Protein Length | 105 Amino acids |
| Molecular weight | 11714 |
| References | 1 PubMed abstract 2757686 2 Sorokin A.V., Skoblov Y.S., Mironov A.A., Zlochevskii M.L.,Dem'Yanova N.G., Rebentish B.A., Kozlov Y.I., Kavsan V.M., Sova V.V.,Debabov V.G.; "Nucleotide sequence of cloned insulin cDNA of Oncorhyncus keta."; Dokl. Biochem. 269:80-83(1983). 3 PubMed abstract 6897724 4 Dem'Yanova N.G., Zlochevskii M.L., Kavsan V.M., Kozlov Y.I.,Petrenko A.I., Polyakova N.E., Prokopenko I.V., Rebentish B.A.,Ryndich A.V., Skoblov Y.S., Sova V.V., Yurin V.L., Yankovskii N.K.,Debabov V.G.; "Cloning of the insulin gene of a fish (Oncorhynchus keta) inEscherichia coli."; Dokl. Biochem. 256:35-38(1981). 5 PubMed abstract 3314270 |
| Domain Name | Insulin |
| Hormone Name | Insulin A chain |
| Mature Hormone Sequence | GIVEQCCHKPCNIFDLQNYCN |
| Position of mature hormone in Pre-Hormone protein | 21 Residues from position (85-105) |
| Receptor | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |