A database of hormones and their receptors |
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HMRbase accession number | 10721 |
Swiss-prot Accession number | P33092 (Sequence in FASTA format) |
Description | Somatotropin (Growth hormone). |
Source organism | Balaenoptera borealis (Sei whale) (Pollack whale) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea;Mysticeti; Balaenopteridae; Balaenoptera. |
Subcellular location | Secreted protein |
Developmental Stage | N/A |
Similarity | Belongs to the somatotropin/prolactin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues |
Protein Length | 190 Amino acids |
Molecular weight | 21835 |
References | 1 PubMed abstract 7115813 2 Osipova T.A., Bulatov A.A., Pankov Y.A.; "Structural studies of tryptic peptides from large cyanogen bromidefragments of sei whale (Balalnoptera borealis) somatotropin."; Bioorg. Khim. 4:1589-1599(1978). |
Domain Name | Hormone_1 |
Hormone Name | Somatotropin |
Mature Hormone Sequence | FPAMPLSSLFANAVLRAQHLHELAADTYKEFERAYIPEGQRYFLQNAQSTGCFSEVIPTPANKDEAQQRSDVELLRFSLLLIQSWLGPVQFLEKAYANELVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNMRSDDALLKNYGLLSCFKKDLHKAETYLRVMKCRRFVESSCAF |
Position of mature hormone in Pre-Hormone protein | 190 Residues from position (1-190) |
Receptor | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |