A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10614
Swiss-prot Accession numberA0MLS4 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin].
Source organismPapio hamadryas (Hamadryas baboon)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
Subcellular locationSecreted protein (By similarity)
Developmental StageN/A
Similarity Belongs to the motilin family.
Tissue SpecificityN/A
Post translational modification O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-98 is essential for obestatin activity (By similarity).
Function Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
Protein Length117 Amino acids
Molecular weight12913
References1   Voruganti V.S., Tejero M.E., Proffitt J.M., Cole S.A.,Freeland-Graves J.H., Comuzzie A.G.; "Quantitative genetic analysis and characterization of ghrelin inbaboons."; Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameObestatin
Mature Hormone SequenceFNAPFDVGIKLSGVQYQQHSQAL
Position of mature hormone in Pre-Hormone protein23 Residues from position (76-98)
ReceptorN/A
Gene IDN/A
PDB IDN/A
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated