A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10580
Swiss-prot Accession numberP19806 (Sequence in FASTA format)
DescriptionCrustacean hyperglycemic hormones isoform A precursor [Contains: CHHprecursor-related peptide A (CPRP-A); Crustacean hyperglycemic hormoneA (CHH-A) (Molt-inhibiting hormone) (MIH)].
Source organismHomarus americanus (American lobster)
Taxonomical ClassificationEukaryota; Metazoa; Arthropoda; Crustacea; Malacostraca;Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;Nephropoidea; Nephropidae; Homarus.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
Tissue SpecificityProduced by the medulla terminalis X-organ in the eyestalks and transported to the sinus gland where they are stored and released. Present also in the ventral nervous system
Post translational modification Stereoinversion of L-Phe (form CHH-A-I) to D-Phe (form CHH-A- II).
FunctionCHH is the most abundant hormone in the sinus gland of isopods and decapods which controls the blood sugar level. Has a secretagogue action over the amylase released from the midgut gland. May act as a stress hormone. MIH may inhibit Y-organs where molting hormone (ecdysteroid) is secreted and a molting cycle is initiated when MIH secretion diminishes or stops
Protein Length134 Amino acids
Molecular weight14996
References1  PubMed abstract 7999796
2  PubMed abstract 1879416
3  PubMed abstract 2169734
4  PubMed abstract 2384751
5  PubMed abstract 8034574
Domain NameCrust_neurohorm  
Hormone NameCrustacean hyperglycemic hormone A
Mature Hormone SequenceQVFDQACKGVYDRNLFKKLDRVCEDCYNLYRKPFVATTCRENCYSNWVFRQCLDDLLLSDVIDEYVSNVQMV
Position of mature hormone in Pre-Hormone protein72 Residues from position (61-132)
ReceptorN/A
Gene IDN/A
PDB IDN/A
Drugpediawiki
Comments!Receptor for this Hormone are either unknown or have not yet been curated