A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10369 |
| Swiss-prot Accession number | Q9UBU3 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 12911 |
| References | 1 PubMed abstract 10604470 2 PubMed abstract 10930375 3 Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4 PubMed abstract 12414809 5 PubMed abstract 12975309 6 PubMed abstract 15489334 7 PubMed abstract 15340161 8 PubMed abstract 11306336 |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGVQYQQHSQAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | Q02643
Detail in HMRbase |
| Gene ID | 51738 |
| PDB ID | 1P7X |
| Drugpedia | wiki |
| Comments |