A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10368
Swiss-prot Accession numberQ9UBU3 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the motilin family.
Tissue SpecificityHighest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy
Post translational modification O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity).
FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation
Protein Length117 Amino acids
Molecular weight12911
References1  PubMed abstract 10604470
2  PubMed abstract 10930375
3   Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000).
4  PubMed abstract 12414809
5  PubMed abstract 12975309
6  PubMed abstract 15489334
7  PubMed abstract 15340161
8  PubMed abstract 11306336
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameGhrelin-27
Mature Hormone SequenceGSSFLSPEHQRVQQRKESKKPPAKLQP
Position of mature hormone in Pre-Hormone protein27 Residues from position (24-50)
ReceptorQ02643    Detail in HMRbase   
Gene ID51738      
PDB ID1P7X      
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