A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10365
Swiss-prot Accession numberQ9QYH7 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin-23; Obestatin-13].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted protein
Developmental StageN/A
Similarity Belongs to the motilin family.
Tissue SpecificityGhrelin is broadly expressed with higher expression in the stomach. Very low levels are detected in the hypothalamus, heart, lung, pancreas, intestine and adipose tissue. Obestatin is most highly expressed in jejunum, and also found in duodenum, stomach, pituitary, ileum, liver, hypothalamus and heart. Expressed in low levels in pancreas, cerebellum, cerebrum, kidney, testis, ovary colon and lung
Post translational modification O-n-octanoylation is essential for ghrelin activity. The replacement of Ser-26 by aromatic tryptophan preserves ghrelin activity. Amidation of Leu-98 is essential for obestatin activity.
FunctionObestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility.
Protein Length117 Amino acids
Molecular weight13176
References1  PubMed abstract 10604470
2  PubMed abstract 10801861
3  PubMed abstract 16284174
4  PubMed abstract 11162448
5  PubMed abstract 11549267
6  PubMed abstract 11306336
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameObestatin-13
Mature Hormone SequenceLSGAQYQQHGRAL
Position of mature hormone in Pre-Hormone protein13 Residues from position (86-98)
ReceptorO08725    Detail in HMRbase   
Gene ID59301      
PDB IDN/A
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