| HMRbase accession number | 10364 |
| Swiss-prot Accession number | Q9QYH7 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin-23; Obestatin-13]. |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Ghrelin is broadly expressed with higher expression in the stomach. Very low levels are detected in the hypothalamus, heart, lung, pancreas, intestine and adipose tissue. Obestatin is most highly expressed in jejunum, and also found in duodenum, stomach, pituitary, ileum, liver, hypothalamus and heart. Expressed in low levels in pancreas, cerebellum, cerebrum, kidney, testis, ovary colon and lung |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity. The replacement of Ser-26 by aromatic tryptophan preserves ghrelin activity. Amidation of Leu-98 is essential for obestatin activity. |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
| Protein Length | 117 Amino acids |
| Molecular weight | 13176 |
| References | 1 PubMed abstract 10604470
2 PubMed abstract 10801861
3 PubMed abstract 16284174
4 PubMed abstract 11162448
5 PubMed abstract 11549267
6 PubMed abstract 11306336
|
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin-23 |
| Mature Hormone Sequence | FNAPFDVGIKLSGAQYQQHGRAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | O08725
Detail in HMRbase
|
| Gene ID | 59301 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors