A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10360 |
| Swiss-prot Accession number | Q9PU41 (Sequence in FASTA format) |
| Description | Cholecystokinins precursor (CCK) [Contains: Cholecystokinin 70(CCK70); Cholecystokinin 8 (CCK8); Cholecystokinin 7 (CCK7)]. |
| Source organism | Gallus gallus (Chicken) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the gastrin/cholecystokinin family. |
| Tissue Specificity | In the small intestine, the major production site is around the vitelline diverticulum |
| Post translational modification | The precursor is cleaved by enzymes to produce a number of active cholecystokinins. |
| Function | This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. It also decreases food intake and regulates gastrointestinal physiological processes. |
| Protein Length | 130 Amino acids |
| Molecular weight | 14091 |
| References | 1 PubMed abstract 11072120 2 PubMed abstract 3620999 3 PubMed abstract 8355559 4 PubMed abstract 8637413 5 PubMed abstract 9039026 6 PubMed abstract 10069039 |
| Domain Name | Gastrin |
| Hormone Name | Cholecystokinin-70 |
| Mature Hormone Sequence | APSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDF |
| Position of mature hormone in Pre-Hormone protein | 70 Residues from position (49-118) |
| Receptor | Q7T1P8
Detail in HMRbase |
| Gene ID | 414884 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |