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HMRbase accession number | 10336 |
Swiss-prot Accession number | Q8R1I2 (Sequence in FASTA format) |
Description | Gastrin-releasing peptide precursor (GRP) [Contains: Neuromedin-C(GRP-10)]. |
Source organism | Mus musculus (Mouse) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | Belongs to the bombesin/neuromedin-B/ranatensin family. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear |
Protein Length | 146 Amino acids |
Molecular weight | 15659 |
References | 1 PubMed abstract 16141072 2 PubMed abstract 15489334 |
Domain Name | Bombesin |
Hormone Name | Gastrin-releasing peptide |
Mature Hormone Sequence | APVSTGAGGGTVLAKMYPRGSHWAVGHLM |
Position of mature hormone in Pre-Hormone protein | 29 Residues from position (24-52) |
Receptor | P21729
Detail in HMRbase |
Gene ID | 225642 |
PDB ID | N/A |
Drugpedia | wiki |
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