A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10014 |
| Swiss-prot Accession number | P06298 (Sequence in FASTA format) |
| Description | Corticotropin-lipotropin A precursor (Pro-opiomelanocortin A) (POMC-A)[Contains: NPP; Melanotropin gamma (Gamma-MSH); Corticotropin(Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH);Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH);Beta-endorphin; Met-enkephalin]. |
| Source organism | Xenopus laevis (African clawed frog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular location | N/A |
| Developmental Stage | N/A |
| Similarity | Belongs to the POMC family. |
| Tissue Specificity | N/A |
| Post translational modification | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Function | N/A |
| Protein Length | 259 Amino acids |
| Molecular weight | 29879 |
| References | 1 PubMed abstract 3754961 2 PubMed abstract 1584015 3 Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 3840481 5 PubMed abstract 2564347 6 PubMed abstract 3754961 7 PubMed abstract 1584015 8 Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. 9 PubMed abstract 3840481 10 PubMed abstract 2564347 |
| Domain Name | NPP ACTH_domain Op_neuropeptide |
| Hormone Name | Melanotropin beta (Beta-MSH) |
| Mature Hormone Sequence | NGNYRMHHFRWGSPPKD |
| Position of mature hormone in Pre-Hormone protein | 17 Residues from position (210-226) |
| Receptor | N/A |
| Gene ID | 380532 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |