A database of hormones and their receptors
Peptide Hormone

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HMRbase accession number10008
Swiss-prot Accession numberQ9PU41 (Sequence in FASTA format)
DescriptionCholecystokinins precursor (CCK) [Contains: Cholecystokinin 70(CCK70); Cholecystokinin 8 (CCK8); Cholecystokinin 7 (CCK7)].
Source organismGallus gallus (Chicken)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityIn the small intestine, the major production site is around the vitelline diverticulum
Post translational modification The precursor is cleaved by enzymes to produce a number of active cholecystokinins.
FunctionThis peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. It also decreases food intake and regulates gastrointestinal physiological processes.
Protein Length130 Amino acids
Molecular weight14091
References1  PubMed abstract 11072120
2  PubMed abstract 3620999
3  PubMed abstract 8355559
4  PubMed abstract 8637413
5  PubMed abstract 9039026
6  PubMed abstract 10069039
Domain NameGastrin  
Hormone NameCholecystokinin
Mature Hormone SequenceQQPAGSHDGSPVAAELQQSLTEPHRHSRAPSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDFGRRSAEEYEYSS
Position of mature hormone in Pre-Hormone protein110 Residues from position (21-130)
ReceptorQ7T1P8    Detail in HMRbase   
Gene ID414884      
PDB IDN/A
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