A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10109 |
| Swiss-prot Accession number | Q9BEF8 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 13007 |
| References | 1 Tomasetto C., Wendling C., Rio M.-C., Poitras P.; "Identification of cDNA encoding MTLRP/ghrelin precursor from dogfundus."; Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
2 Doi K., Kojima M., Hosoda H., Kaiya H., Matsuo H., Kangawa K.; "Dog ghrelin."; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGPQYHQHGQAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | N/A |
| Gene ID | 403587 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
| HMRbase accession number | 10111 |
| Swiss-prot Accession number | Q6BEG7 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Capra hircus (Goat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Capra. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-97 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 116 Amino acids |
| Molecular weight | 12935 |
| References | 1 Lin X., Miyazato M., Kaiya H., Ida T., Kangawa K.; "cDNA cloning of feline and caprine ghrelin."; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFNIGIKLSGAQSLQHGQTL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (75-97) |
| Receptor | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
| HMRbase accession number | 10114 |
| Swiss-prot Accession number | Q6BEG6 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Felis silvestris catus (Cat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;Felinae; Felis. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility. |
| Protein Length | 117 Amino acids |
| Molecular weight | 12956 |
| References | 1 Lin X., Miyazato M., Kaiya H., Ida T., Kangawa K.; "cDNA cloning of feline and caprine ghrelin."; Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
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| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGAQYHQHGQAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | N/A |
| Gene ID | 493844 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
| HMRbase accession number | 10348 |
| Swiss-prot Accession number | Q9BDJ6 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-97 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 116 Amino acids |
| Molecular weight | 12793 |
| References | 1 Kita K., Harada K., Yokota H.; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
2 Li C., Lobo S., Wang Z., Fu A., Meng Y., Murdoch B., Hansen C.,Moore S.; "A full length genomic sequence of the bovine ghrelin gene."; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. 3 Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFNIGIKLAGAQSLQHGQTL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (75-97) |
| Receptor | Q9BDH9 Detail in HMRbase Q9N1F8 Detail in HMRbase Q9TUJ0 Detail in HMRbase Q9TUJ1 Detail in HMRbase |
| Gene ID | 281192 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10352 |
| Swiss-prot Accession number | Q9GKY5 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-99 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 118 Amino acids |
| Molecular weight | 12786 |
| References | 1 Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
2 Rousselle J., Lacroix D., Dubreuil P.; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. 3 Ying M., Yang Z.; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPCDVGIKLSGAQSDQHGQPL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (77-99) |
| Receptor | P34999
Detail in HMRbase |
| Gene ID | 396728 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10369 |
| Swiss-prot Accession number | Q9UBU3 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity. The O-n- decanoylated forms Ghrelin-27-C10 and Ghrelin-28-C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. A small fraction of ghrelin, ghrelin-28-C10:1, may be modified with an unsaturated carboxylic acid. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 12911 |
| References | 1 PubMed abstract 10604470 2 PubMed abstract 10930375 3 Wajnrajch M.P., Ten I.S., Gertner J.M., Leibel R.L.; "Genomic organization of the human Ghrelin gene."; J. Endocr. Genet. 1:231-233(2000). 4 PubMed abstract 12414809 5 PubMed abstract 12975309 6 PubMed abstract 15489334 7 PubMed abstract 15340161 8 PubMed abstract 11306336 |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGVQYQQHSQAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | Q02643
Detail in HMRbase |
| Gene ID | 51738 |
| PDB ID | 1P7X |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10614 |
| Swiss-prot Accession number | A0MLS4 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Papio hamadryas (Hamadryas baboon) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 12913 |
| References | 1 Voruganti V.S., Tejero M.E., Proffitt J.M., Cole S.A.,Freeland-Graves J.H., Comuzzie A.G.; "Quantitative genetic analysis and characterization of ghrelin inbaboons."; Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
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| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGVQYQQHSQAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Receptor for this Hormone are either unknown or have not yet been curated |
| HMRbase accession number | 11513 |
| Swiss-prot Accession number | Q9EQX0 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin; Obestatin]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein |
| Developmental Stage | Levels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning. |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Mainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). The O-n-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 13207 |
| References | 1 PubMed abstract 10930375 2 Kojima M.; "Mouse mRNA for preproghrelin."; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. 3 Tanaka M., Hayashida Y., Iguchi T., Nakao N., Nakai N., Nakashima K.; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 16141072 5 PubMed abstract 15746259 6 PubMed abstract 11306336 |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGAQYQQHGRAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | Q99P50
Detail in HMRbase |
| Gene ID | 58991 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |