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HMRbase accession number | 10043 |
Swiss-prot Accession number | P82965 (Sequence in FASTA format) |
Description | Antidiuretic factor A (ADFa) (ADF) (Antidiuretic hormone A) (ADHA). |
Source organism | Tenebrio molitor (Yellow mealworm) |
Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;Tenebrionidae; Tenebrio. |
Subcellular location | Secreted |
Developmental Stage | N/A |
Similarity | To T.molitor cuticular protein LPCP29 C-terminal region. |
Tissue Specificity | N/A |
Post translational modification | N/A |
Function | Strong inhibitor of fluid secretion by the Malpighian tubules. Uses cGMP as a second messenger and inhibits fluid production by decreasing cAMP concentration. Reduces isosmotic fluid secretion by inhibiting electroneutral and non-conductive transport pathways. Reverses the stimulatory effect of diuretic hormone I |
Protein Length | 14 Amino acids |
Molecular weight | 1543 |
References | 1 PubMed abstract 11756661 2 PubMed abstract 11893763 3 PubMed abstract 15235016 4 PubMed abstract 11756661 5 PubMed abstract 11893763 6 PubMed abstract 15235016 |
Domain Name | N/A |
Hormone Name | Antidiuretic factor A |
Mature Hormone Sequence | VVNTPGHAVSYHVY |
Position of mature hormone in Pre-Hormone protein | 14 Residues from position (1-14) |
Receptor | N/A |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
Comments | !Receptor for this Hormone are either unknown or have not yet been curated |