A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21196 |
| Swiss-prot Accession number | Q9PVZ4 (Sequence in FASTA format) |
| Description | Insulin receptor precursor (EC 2.7.10.1) (IR) (Xe-InsR) (XTK-1b)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. |
| Source organism | Xenopus laevis (African clawed frog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein |
| Developmental Stage | Expressed both maternally and zygotically. Weakly expressed in embryos through gastrulation and neurulation. Expressed in the tailbud stage and in older tadpoles. |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 3 fibronectin type-III domains. Contains 1 protein kinase domain. |
| Tissue Specificity | Localized mainly to the envelope in oocytes. Localized to the animal hemisphere during early embryonic cleavage. Expressed during organogenesis in regions of ecto- and mesodermic origins. Expressed in the entire encephalon, the otic and optic vesicles, the gills, the somites and the pronephric tubules of the embryo. Also found in adult liver, muscle and regenerated forelimbs. |
| Post translational modification | Autophosphorylated on tyrosine residues in response to insulin. |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. May be required for forelimb regeneration. |
| Protein Length | 1362 Amino acids |
| Molecular weight | 153757 |
| Domain Name | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| References | 1 PubMed abstract 10446274 2 PubMed abstract 1648732 3 PubMed abstract 1847619 4 PubMed abstract 7595277 |
| Hormone | P12706 Detail in HMRbase P12707 Detail in HMRbase |
| Gene ID | 398006 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |