A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10115 |
| Swiss-prot Accession number | Q9GKY5 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-99 is essential for obestatin activity (By similarity). |
| Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
| Protein Length | 118 Amino acids |
| Molecular weight | 12786 |
| References | 1 Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
2 Rousselle J., Lacroix D., Dubreuil P.; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. 3 Ying M., Yang Z.; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Ghrelin |
| Mature Hormone Sequence | GSSFLSPEHQKVQQRKESKKPAAKLKPR |
| Position of mature hormone in Pre-Hormone protein | 28 Residues from position (25-52) |
| Receptor | P34999
Detail in HMRbase |
| Gene ID | 396728 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10352 |
| Swiss-prot Accession number | Q9GKY5 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Sus scrofa (Pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-99 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 118 Amino acids |
| Molecular weight | 12786 |
| References | 1 Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
2 Rousselle J., Lacroix D., Dubreuil P.; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. 3 Ying M., Yang Z.; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPCDVGIKLSGAQSDQHGQPL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (77-99) |
| Receptor | P34999
Detail in HMRbase |
| Gene ID | 396728 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |