A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11512 |
| Swiss-prot Accession number | Q9EQX0 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin; Obestatin]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein |
| Developmental Stage | Levels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning. |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Mainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). The O-n-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
| Protein Length | 117 Amino acids |
| Molecular weight | 13207 |
| References | 1 PubMed abstract 10930375 2 Kojima M.; "Mouse mRNA for preproghrelin."; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. 3 Tanaka M., Hayashida Y., Iguchi T., Nakao N., Nakai N., Nakashima K.; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 16141072 5 PubMed abstract 15746259 6 PubMed abstract 11306336 |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Ghrelin |
| Mature Hormone Sequence | GSSFLSPEHQKAQQRKESKKPPAKLQPR |
| Position of mature hormone in Pre-Hormone protein | 28 Residues from position (24-51) |
| Receptor | Q99P50
Detail in HMRbase |
| Gene ID | 58991 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 11513 |
| Swiss-prot Accession number | Q9EQX0 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin; Obestatin]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein |
| Developmental Stage | Levels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning. |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | Mainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). The O-n-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. Amidation of Leu-98 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 117 Amino acids |
| Molecular weight | 13207 |
| References | 1 PubMed abstract 10930375 2 Kojima M.; "Mouse mRNA for preproghrelin."; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. 3 Tanaka M., Hayashida Y., Iguchi T., Nakao N., Nakai N., Nakashima K.; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 16141072 5 PubMed abstract 15746259 6 PubMed abstract 11306336 |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFDVGIKLSGAQYQQHGRAL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (76-98) |
| Receptor | Q99P50
Detail in HMRbase |
| Gene ID | 58991 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |