A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10347 |
| Swiss-prot Accession number | Q9BDJ6 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-97 is essential for obestatin activity (By similarity). |
| Function | Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation |
| Protein Length | 116 Amino acids |
| Molecular weight | 12793 |
| References | 1 Kita K., Harada K., Yokota H.; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
2 Li C., Lobo S., Wang Z., Fu A., Meng Y., Murdoch B., Hansen C.,Moore S.; "A full length genomic sequence of the bovine ghrelin gene."; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. 3 Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Ghrelin |
| Mature Hormone Sequence | GSSFLSPEHQKLQRKEAKKPSGRLKPR |
| Position of mature hormone in Pre-Hormone protein | 27 Residues from position (24-50) |
| Receptor | Q9BDH9 Detail in HMRbase Q9N1F8 Detail in HMRbase Q9TUJ0 Detail in HMRbase Q9TUJ1 Detail in HMRbase |
| Gene ID | 281192 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 10348 |
| Swiss-prot Accession number | Q9BDJ6 (Sequence in FASTA format) |
| Description | Appetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin]. |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the motilin family. |
| Tissue Specificity | N/A |
| Post translational modification | O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-97 is essential for obestatin activity (By similarity). |
| Function | Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility |
| Protein Length | 116 Amino acids |
| Molecular weight | 12793 |
| References | 1 Kita K., Harada K., Yokota H.; Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
2 Li C., Lobo S., Wang Z., Fu A., Meng Y., Murdoch B., Hansen C.,Moore S.; "A full length genomic sequence of the bovine ghrelin gene."; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. 3 Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases. |
| Domain Name | Motilin_assoc Motilin_ghrelin |
| Hormone Name | Obestatin |
| Mature Hormone Sequence | FNAPFNIGIKLAGAQSLQHGQTL |
| Position of mature hormone in Pre-Hormone protein | 23 Residues from position (75-97) |
| Receptor | Q9BDH9 Detail in HMRbase Q9N1F8 Detail in HMRbase Q9TUJ0 Detail in HMRbase Q9TUJ1 Detail in HMRbase |
| Gene ID | 281192 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |