A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21289 |
| Swiss-prot Accession number | Q62986 (Sequence in FASTA format) |
| Description | RecName: Estrogen receptor beta;ER-beta;Alternative Name: Nuclear receptor subfamily 3 group A member 2; |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis. |
| Post translational modification | N/A |
| Function | Binds estrogens with an affinity similar to that of ER- alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER- alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action. |
| Protein Length | 530 Amino acids |
| Molecular weight | 59152 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 8650195 2 PubMed abstract 9600083 3 PubMed abstract 9492041 4 PubMed abstract 11818503 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 25149 |
| PDB ID | 1HJ1 1QKN 2J7X 2J7Y |
| Drugpedia | wiki |
| Comments |