A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21361 |
| Swiss-prot Accession number | Q62685 (Sequence in FASTA format) |
| Description | RecName: Oxysterols receptor LXR-alpha;Alternative Name: Liver X receptor alpha;Alternative Name: Nuclear orphan receptor LXR-alpha;Alternative Name: Nuclear receptor subfamily 1 group H member 3;Alternative Name: RLD-1; |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | In adults it is expressed in spleen, pituitary, lung, liver, and fat. Weaker expression is observed in several other tissues. |
| Post translational modification | N/A |
| Function | Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis (By similarity). |
| Protein Length | 445 Amino acids |
| Molecular weight | 50555 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7935418 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |