A database of hormones and their receptors
Receptor

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HMRbase accession number21109
Swiss-prot Accession numberQ61606 (Sequence in FASTA format)
DescriptionGlucagon receptor precursor (GL-R).
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationCell membrane; multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 2 family.
Tissue SpecificityExpressed predominantly in liver, kidney, adrenal, lung and stomach, while lower levels of expression are detected in brown and white adipose tissue, cerebellum, duodenum and heart.
Post translational modificationN/A
Function This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Protein Length485 Amino acids
Molecular weight54872
Domain Name7tm_2  HRM  
References1  PubMed abstract 7590348
2  PubMed abstract 8156917
3  PubMed abstract 7590348
4  PubMed abstract 8156917
HormoneP55095   Detail in HMRbase   
Gene IDN/A
PDB IDN/A
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