A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 10326 |
| Swiss-prot Accession number | Q5XXR2 (Sequence in FASTA format) |
| Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the melanin-concentrating hormone family. |
| Tissue Specificity | N/A |
| Post translational modification | Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6 (By similarity). MCH is a cyclic peptide (By similarity). |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal |
| Protein Length | 165 Amino acids |
| Molecular weight | 18644 |
| References | 1 Steflik J., Waters S.M.; "Canine pro-melanin-concentrating hormone."; Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
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| Domain Name | Pro-MCH |
| Hormone Name | Melanin-concentrating hormone |
| Mature Hormone Sequence | DFDMLRCMLGRVYRPCWQV |
| Position of mature hormone in Pre-Hormone protein | 19 Residues from position (147-165) |
| Receptor | Q8MIP5 Detail in HMRbase Q8MIP6 Detail in HMRbase |
| Gene ID | 449022 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 11503 |
| Swiss-prot Accession number | Q5XXR2 (Sequence in FASTA format) |
| Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Source organism | Canis familiaris (Dog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;Canis. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the melanin-concentrating hormone family. |
| Tissue Specificity | N/A |
| Post translational modification | Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6 (By similarity). MCH is a cyclic peptide (By similarity). |
| Function | N/A |
| Protein Length | 165 Amino acids |
| Molecular weight | 18644 |
| References | 1 Steflik J., Waters S.M.; "Canine pro-melanin-concentrating hormone."; Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
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| Domain Name | Pro-MCH |
| Hormone Name | Neuropeptide-glutamic acid-isoleucine |
| Mature Hormone Sequence | EIGDEENSAKFPI |
| Position of mature hormone in Pre-Hormone protein | 13 Residues from position (131-143) |
| Receptor | Q8MIP5 Detail in HMRbase Q8MIP6 Detail in HMRbase |
| Gene ID | 449022 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |