A database of hormones and their receptors
Receptor

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HMRbase accession number21635
Swiss-prot Accession numberQ15722 (Sequence in FASTA format)
DescriptionLeukotriene B4 receptor 1;LTB4-R 1;Alternative Name: P2Y purinoceptor 7;P2Y7;Alternative Name: Chemoattractant receptor-like 1;Alternative Name: G-protein coupled receptor 16
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationCell membrane; Multi-pass membrane protein
Developmental StageN/A
Similarity Belongs to the G-protein coupled receptor 1 family.
Tissue SpecificityExpressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues.
Post translational modification Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.
Function Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Protein Length352 Amino acids
Molecular weight37557
Domain Name7tm_1  
References1  PubMed abstract 8702478
2  PubMed abstract 8558062
3  PubMed abstract 9177352
4  PubMed abstract 8921391
5  PubMed abstract 10934229
6  PubMed abstract 15489334
7  PubMed abstract 12077128
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Gene ID1241      
PDB IDN/A
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