A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21418 |
| Swiss-prot Accession number | Q07869 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor alpha;PPAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group C member 1 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Skeletal muscle, liver, heart and kidney. |
| Post translational modification | N/A |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. |
| Protein Length | 468 Amino acids |
| Molecular weight | 52225 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7684926 2 PubMed abstract 7981125 3 PubMed abstract 8993548 4 PubMed abstract 15461802 5 PubMed abstract 10591208 6 PubMed abstract 9238002 7 PubMed abstract 10681503 8 PubMed abstract 11698662 9 PubMed abstract 11587644 10 PubMed abstract 11845213 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 5465 |
| PDB ID | 1I7G 1K7L 1KKQ 2NPA 2P54 2REW |
| Drugpedia | wiki |
| Comments |