| HMRbase accession number | 11482 |
| Swiss-prot Accession number | P56942 (Sequence in FASTA format) |
| Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | Expression is enhanced between postnatal days 10 and 15. |
| Similarity | Belongs to the MCH family. |
| Tissue Specificity | Predominantly expressed in hypothalamus. Also found in heart, intestine, spleen and testis (spermatogonia, early spermatocytes and Sertoli cells). In brain only mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly |
| Post translational modification | Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide. |
| Function | N/A |
| Protein Length | 166 Amino acids |
| Molecular weight | 18645 |
| References | 1 Breton C., Presse F., Hervieu G., Nahon J.-L.; "Structure and regulation of the mouse melanin-concentrating hormonemRNA and gene."; Mol. Cell. Neurosci. 4:271-284(1993).
2 PubMed abstract 10037747
3 PubMed abstract 8724342
|
| Domain Name | Pro-MCH |
| Hormone Name | Neuropeptide-glutamic acid-isoleucine |
| Mature Hormone Sequence | EIGDEENSAKFPI |
| Position of mature hormone in Pre-Hormone protein | 13 Residues from position (132-144) |
| Receptor | Q8K3M8 Detail in HMRbase
Q3UY93
Detail in HMRbase
|
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
| HMRbase accession number | 11483 |
| Swiss-prot Accession number | P56942 (Sequence in FASTA format) |
| Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | Expression is enhanced between postnatal days 10 and 15. |
| Similarity | Belongs to the MCH family. |
| Tissue Specificity | Predominantly expressed in hypothalamus. Also found in heart, intestine, spleen and testis (spermatogonia, early spermatocytes and Sertoli cells). In brain only mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly |
| Post translational modification | Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide. |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal |
| Protein Length | 166 Amino acids |
| Molecular weight | 18645 |
| References | 1 Breton C., Presse F., Hervieu G., Nahon J.-L.; "Structure and regulation of the mouse melanin-concentrating hormonemRNA and gene."; Mol. Cell. Neurosci. 4:271-284(1993).
2 PubMed abstract 10037747
3 PubMed abstract 8724342
|
| Domain Name | Pro-MCH |
| Hormone Name | Melanin-concentrating hormone |
| Mature Hormone Sequence | DFDMLRCMLGRVYRPCWQV |
| Position of mature hormone in Pre-Hormone protein | 19 Residues from position (148-166) |
| Receptor | Q8K3M8 Detail in HMRbase
Q3UY93
Detail in HMRbase
|
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors