A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21339 |
| Swiss-prot Accession number | P51843 (Sequence in FASTA format) |
| Description | RecName: Nuclear receptor subfamily 0 group B member 1;Alternative Name: Nuclear receptor DAX-1;Alternative Name: DSS-AHC critical region on the X chromosome protein 1; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR0 subfamily. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). |
| Protein Length | 470 Amino acids |
| Molecular weight | 51718 |
| Domain Name | Hormone_recep |
| References | 1 PubMed abstract 7990953 2 PubMed abstract 8675564 3 PubMed abstract 15489334 4 PubMed abstract 10713076 5 PubMed abstract 12482977 6 PubMed abstract 15589120 7 PubMed abstract 16146703 8 PubMed abstract 16709599 9 PubMed abstract 7990958 10 PubMed abstract 9003500 11 PubMed abstract 9360549 12 PubMed abstract 9063431 13 PubMed abstract 9415399 14 PubMed abstract 9529340 15 PubMed abstract 9486644 16 PubMed abstract 10323730 17 PubMed abstract 10341858 18 PubMed abstract 10675358 19 PubMed abstract 11113848 20 PubMed abstract 10848616 21 PubMed abstract 11748852 22 PubMed abstract 11443184 23 PubMed abstract 11788621 24 PubMed abstract 12629128 25 PubMed abstract 15800903 |
| Hormone | Detail in HMRbase |
| Gene ID | 190 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |