A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 22953 |
| Swiss-prot Accession number | P48357 (Sequence in FASTA format) |
| Description | Leptin receptor;LEP-R;Alternative Name: OB receptor;OB-R;Alternative Name: HuB219;Alternative Name: CD_antigen=CD295;Precursor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like (immunoglobulin-like) domain. |
| Tissue Specificity | Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus. |
| Post translational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). |
| Protein Length | 1165 Amino acids |
| Molecular weight | 132494 |
| Domain Name | fn3 Lep_receptor_Ig |
| References | 1 PubMed abstract 8548812 2 PubMed abstract 8805376 3 PubMed abstract 8616721 4 PubMed abstract 9158141 5 PubMed abstract 9061609 6 PubMed abstract 9929394 7 PubMed abstract 9600917 8 PubMed abstract 9786864 9 PubMed abstract 16335952 10 PubMed abstract 8666155 11 PubMed abstract 9144432 12 PubMed abstract 9287054 13 PubMed abstract 9175732 14 PubMed abstract 9860295 15 PubMed abstract 18987736 |
| Hormone | P41159 Detail in HMRbase A4D0Y8 Detail in HMRbase B2R8Y2 Detail in HMRbase Q6NT58 Detail in HMRbase |
| Gene ID | 3953 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |