A database of hormones and their receptors |
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HMRbase accession number | 21046 |
Swiss-prot Accession number | P47799 (Sequence in FASTA format) |
Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
Source organism | Equus caballus (Horse) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | N/A |
Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (By similarity). |
Function | Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Among all mammalian FSH receptors, on the horse receptor does not bind LH/chorionic gonadotrophin (CG). |
Protein Length | 694 Amino acids |
Molecular weight | 78005 |
Domain Name | N/A |
References | 1 PubMed abstract 8198575 2 PubMed abstract 8198575 |
Hormone | P01220 Detail in HMRbase P01226 Detail in HMRbase |
Gene ID | N/A |
PDB ID | N/A |
Drugpedia | wiki |
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