A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21648 |
| Swiss-prot Accession number | P46098 (Sequence in FASTA format) |
| Description | 5-hydroxytryptamine receptor 3A;Alternative Name: 5-HT3R;Alternative Name: 5-HT3A;Alternative Name: 5-HT-3;Alternative Name: Serotonin receptor 3A;Alternative Name: Serotonin-gated ion channel receptor; Precursor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the ligand-gated ionic channel (TC 1.A.9) family. |
| Tissue Specificity | Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta. |
| Post translational modification | N/A |
| Function | This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. |
| Protein Length | 478 Amino acids |
| Molecular weight | 55280 |
| Domain Name | Neur_chan_LBD Neur_chan_memb |
| References | 1 PubMed abstract 7565620 2 PubMed abstract 8848005 3 PubMed abstract 9928262 4 PubMed abstract 10670426 5 PubMed abstract 15489334 6 PubMed abstract 9950429 7 PubMed abstract 10521471 8 PubMed abstract 12867984 9 PubMed abstract 15809299 10 PubMed abstract 17392525 11 PubMed abstract 15293096 12 PubMed abstract 16487942 |
| Hormone | Detail in HMRbase |
| Gene ID | 3359 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |