A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11531 |
| Swiss-prot Accession number | P41159 (Sequence in FASTA format) |
| Description | Leptin;Alternative Name: Obesity factor;Alternative Name: Obese protein; Precursor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted |
| Developmental Stage | N/A |
| Similarity | Belongs to the leptin family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
| Protein Length | 167 Amino acids |
| Molecular weight | 18641 |
| References | 1 PubMed abstract 7984236 2 PubMed abstract 7789654 3 PubMed abstract 8626726 4 PubMed abstract 7499240 5 PubMed abstract 8621021 6 PubMed abstract 15489334 7 PubMed abstract 10428856 8 PubMed abstract 9166907 9 PubMed abstract 9144295 10 PubMed abstract 9500540 |
| Domain Name | Leptin |
| Hormone Name | Leptin |
| Mature Hormone Sequence | |
| Position of mature hormone in Pre-Hormone protein | |
| Receptor | P48357 Detail in HMRbase O95214 Detail in HMRbase O15243 Detail in HMRbase A8K2E3 Detail in HMRbase Q6FHL5 Detail in HMRbase Q6FHL7 Detail in HMRbase |
| Gene ID | 3952 |
| PDB ID | 1AX8 |
| Drugpedia | wiki |
| Comments |