A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21041 |
| Swiss-prot Accession number | P35379 (Sequence in FASTA format) |
| Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Isoform FSH-R1: Cell membrane; multi-pass membrane protein. Isoform FSH-R2: Cell membrane; multi-pass membrane protein. Isoform FSH-R3: Cell surface |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
| Tissue Specificity | Isoform FSH-R3 is expressed in ovary and testis, but not in kidney. |
| Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (By similarity). |
| Function | Receptor for follicle-stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. |
| Protein Length | 695 Amino acids |
| Molecular weight | 78238 |
| Domain Name | N/A |
| References | 1 PubMed abstract 8394255 2 PubMed abstract 8439338 3 PubMed abstract 9364440 4 PubMed abstract 10527886 5 PubMed abstract 9364442 6 PubMed abstract 8394255 7 PubMed abstract 8439338 8 PubMed abstract 9364440 9 PubMed abstract 10527886 10 PubMed abstract 9364442 |
| Hormone | P01218 Detail in HMRbase P01227 Detail in HMRbase |
| Gene ID | 443299 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |