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HMRbase accession number | 21013 |
Swiss-prot Accession number | P30875 (Sequence in FASTA format) |
Description | Somatostatin receptor type 2 (SS2R) (SRIF-1). |
Source organism | Mus musculus (Mouse) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
Subcellular location | Cell membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. |
Tissue Specificity | Cerebrum and kidney. |
Post translational modification | N/A |
Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. |
Protein Length | 369 Amino acids |
Molecular weight | 41222 |
Domain Name | 7tm_1 |
References | 1 PubMed abstract 1346068 2 PubMed abstract 1397330 3 PubMed abstract 11278805 4 PubMed abstract 7913111 5 PubMed abstract 8104154 6 PubMed abstract 1346068 7 PubMed abstract 1397330 8 PubMed abstract 11278805 9 PubMed abstract 7913111 10 PubMed abstract 8104154 |
Hormone | P60041 Detail in HMRbase |
Gene ID | 20606 |
PDB ID | N/A |
Drugpedia | wiki |
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