A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21639 |
| Swiss-prot Accession number | P25090 (Sequence in FASTA format) |
| Description | N-formyl peptide receptor 2;Alternative Name: FMLP-related receptor I;FMLP-R-I;Alternative Name: Formyl peptide receptor-like 1;Alternative Name: Lipoxin A4 receptor;LXA4 receptor;Alternative Name: RFP;Alternative Name: HM63 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis. |
| Post translational modification | N/A |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). |
| Protein Length | 351 Amino acids |
| Molecular weight | 38964 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1612600 2 PubMed abstract 1511907 3 PubMed abstract 1374236 4 PubMed abstract 1373134 5 PubMed abstract 7505609 6 PubMed abstract 9547339 7 PubMed abstract 15057824 8 PubMed abstract 15489334 9 PubMed abstract 9151906 |
| Hormone | Detail in HMRbase |
| Gene ID | 2358 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |