A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20998 |
| Swiss-prot Accession number | P23945 (Sequence in FASTA format) |
| Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
| Tissue Specificity | Sertoli cells and ovarian granulosa cells. |
| Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (By similarity). |
| Function | Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
| Protein Length | 695 Amino acids |
| Molecular weight | 78295 |
| Domain Name | N/A |
| References | 1 PubMed abstract 1709010 2 PubMed abstract 1301382 3 PubMed abstract 1322283 4 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 5 PubMed abstract 15489334 6 PubMed abstract 1359889 7 PubMed abstract 7926278 8 PubMed abstract 7916967 9 PubMed abstract 8747461 10 PubMed abstract 15662415 11 PubMed abstract 7553856 12 PubMed abstract 9100567 13 PubMed abstract 9851774 14 PubMed abstract 9769327 15 PubMed abstract 10391209 16 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 17 PubMed abstract 12059813 18 PubMed abstract 11889179 19 PubMed abstract 12930927 20 PubMed abstract 12930928 21 PubMed abstract 1709010 22 PubMed abstract 1301382 23 PubMed abstract 1322283 24 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 25 PubMed abstract 15489334 26 PubMed abstract 1359889 27 PubMed abstract 7926278 28 PubMed abstract 7916967 29 PubMed abstract 8747461 30 PubMed abstract 15662415 31 PubMed abstract 7553856 32 PubMed abstract 9100567 33 PubMed abstract 9851774 34 PubMed abstract 9769327 35 PubMed abstract 10391209 36 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 37 PubMed abstract 12059813 38 PubMed abstract 11889179 39 PubMed abstract 12930927 40 PubMed abstract 12930928 41 PubMed abstract 1709010 42 PubMed abstract 1301382 43 PubMed abstract 1322283 44 Kopatz S.A., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 45 PubMed abstract 15489334 46 PubMed abstract 1359889 47 PubMed abstract 7926278 48 PubMed abstract 7916967 49 PubMed abstract 8747461 50 PubMed abstract 15662415 51 PubMed abstract 7553856 52 PubMed abstract 9100567 53 PubMed abstract 9851774 54 PubMed abstract 9769327 55 PubMed abstract 10391209 56 Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N.,Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L.,Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q.,Lander E.S.; Nat. Genet. 23:373-373(1999). 57 PubMed abstract 12059813 58 PubMed abstract 11889179 59 PubMed abstract 12930927 60 PubMed abstract 12930928 |
| Hormone | P01215 Detail in HMRbase P01225 Detail in HMRbase |
| Gene ID | 2492 |
| PDB ID | 1XUN 1XWD |
| Drugpedia | wiki |
| Comments |