A database of hormones and their receptors
Receptor

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HMRbase accession number21419
Swiss-prot Accession numberP23204 (Sequence in FASTA format)
DescriptionPeroxisome proliferator-activated receptor alpha;PPAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group C member 1
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationNucleus
Developmental StageIt appears first at 13.5 dpc and increases until birth.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue SpecificityHighly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.
Post translational modificationN/A
Function Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.
Protein Length468 Amino acids
Molecular weight52347
Domain NameHormone_recep  zf-C4  
References1  PubMed abstract 2129546
2  PubMed abstract 8123021
3  PubMed abstract 15489334
4  PubMed abstract 7588749
5  PubMed abstract 9325263
6  PubMed abstract 9627117
7  PubMed abstract 10788465
HormoneDetail in HMRbase   
Detail in HMRbase   
Gene ID19013      
PDB IDN/A
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