A database of hormones and their receptors |
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HMRbase accession number | 20992 |
Swiss-prot Accession number | P20395 (Sequence in FASTA format) |
Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
Source organism | Rattus norvegicus (Rat) |
Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
Subcellular location | Membrane; multi-pass membrane protein |
Developmental Stage | N/A |
Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
Tissue Specificity | Sertoli cells and ovarian granulosa cells. |
Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. |
Function | Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. |
Protein Length | 692 Amino acids |
Molecular weight | 77681 |
Domain Name | N/A |
References | 1 PubMed abstract 2126341 2 PubMed abstract 1738373 3 PubMed abstract 7776966 4 PubMed abstract 2126341 5 PubMed abstract 1738373 6 PubMed abstract 7776966 |
Hormone | P11962 Detail in HMRbase P18427 Detail in HMRbase |
Gene ID | 25449 |
PDB ID | N/A |
Drugpedia | wiki |
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