A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11423 |
| Swiss-prot Accession number | P20382 (Sequence in FASTA format) |
| Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the melanin-concentrating hormone family. |
| Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly |
| Post translational modification | Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide. |
| Function | N/A |
| Protein Length | 165 Amino acids |
| Molecular weight | 18723 |
| References | 1 PubMed abstract 2149166 2 PubMed abstract 8326825 3 PubMed abstract 10037747 4 PubMed abstract 9191099 |
| Domain Name | Pro-MCH |
| Hormone Name | Neuropeptide-glutamic acid-isoleucine |
| Mature Hormone Sequence | EIGDEENSAKFPI |
| Position of mature hormone in Pre-Hormone protein | 13 Residues from position (131-143) |
| Receptor | Q99705 Detail in HMRbase Q969V1 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |
| HMRbase accession number | 11424 |
| Swiss-prot Accession number | P20382 (Sequence in FASTA format) |
| Description | Pro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the melanin-concentrating hormone family. |
| Tissue Specificity | Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood. In brain exclusively mature MCH and NEI peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly |
| Post translational modification | Differentially processed in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide. |
| Function | MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation |
| Protein Length | 165 Amino acids |
| Molecular weight | 18723 |
| References | 1 PubMed abstract 2149166 2 PubMed abstract 8326825 3 PubMed abstract 10037747 4 PubMed abstract 9191099 |
| Domain Name | Pro-MCH |
| Hormone Name | Melanin-concentrating hormone |
| Mature Hormone Sequence | FPIGRRDFDMLRCMLGRVYRPCWQV |
| Position of mature hormone in Pre-Hormone protein | 19 Residues from position (147-165) |
| Receptor | Q99705 Detail in HMRbase Q969V1 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |