A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20989 |
| Swiss-prot Accession number | P16882 (Sequence in FASTA format) |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; single-pass type I membrane protein. Isoform 2: Secreted protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity) |
| Developmental Stage | During gestation, both hepatic and serum expression begins at day 9. Levels increased 8-fold in liver and 30-fold in serum by late gestation. Levels of isoform 1 and isoform 2 similarly begin at day 9 with isoform 1 expression reaching maximum levels by day 13, isoform 2 levels continue to increase until the end of pregnancy. |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Tissue Specificity | Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver. |
| Post translational modification | On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. |
| Protein Length | 650 Amino acids |
| Molecular weight | 72783 |
| Domain Name | N/A |
| References | 1 PubMed abstract 2739661 2 PubMed abstract 7988474 3 PubMed abstract 10425445 4 PubMed abstract 15489334 5 PubMed abstract 7894338 6 Zhou Y., He L., Kopchick J.J.; Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases. 7 Rowland J.E., Waters M.J.; "Mouse growth hormone receptor cytoplasmic exons 9 and 10 genomicclone with flanking intronic sequence."; Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases. 8 PubMed abstract 3398846 9 PubMed abstract 12379490 |
| Hormone | P06880 Detail in HMRbase |
| Gene ID | 14600 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |