A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20985 |
| Swiss-prot Accession number | P16310 (Sequence in FASTA format) |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; single-pass type I membrane protein. Isoform 2: Secreted protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. Isoform 2 is mainly secreted. In adipose tissue, isoform 2 is mostly membrane associated |
| Developmental Stage | Expression is low at birth. Increases to adult levels after 5 weeks. |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Tissue Specificity | Highest expression in liver. Also expressed in heart, kidney and muscle. |
| Post translational modification | On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2. Phosphorylation on either (or all of) Tyr-534, Tyr-566 and/or Tyr-627 is required for STAT5 activation. Phosphorylation on Tyr-333 would seem necessary for JAK2 activation. On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. |
| Protein Length | 638 Amino acids |
| Molecular weight | 71237 |
| Domain Name | N/A |
| References | 1 PubMed abstract 2722883 2 PubMed abstract 2792761 3 PubMed abstract 1446642 4 PubMed abstract 8921876 5 PubMed abstract 8063815 6 PubMed abstract 7615519 7 PubMed abstract 10585430 8 PubMed abstract 7545168 9 PubMed abstract 9231797 |
| Hormone | P01244 Detail in HMRbase |
| Gene ID | 25235 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |