A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20984 |
| Swiss-prot Accession number | P15208 (Sequence in FASTA format) |
| Description | Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 3 fibronectin type-III domains. Contains 1 protein kinase domain. |
| Tissue Specificity | N/A |
| Post translational modification | Autophosphorylated on tyrosine residues in response to insulin (By similarity). Phosphorylation of Tyr-989 is required for IRS1- and SHC1- binding (By similarity). |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. |
| Protein Length | 1372 Amino acids |
| Molecular weight | 155640 |
| Domain Name | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| References | 1 PubMed abstract 2557333 2 PubMed abstract 2602374 3 PubMed abstract 9447983 |
| Hormone | P01326 Detail in HMRbase |
| Gene ID | 16337 |
| PDB ID | 1LK2 |
| Drugpedia | wiki |
| Comments |