A database of hormones and their receptors
Peptide Hormone

Search Result - 1

HMRbase accession number11409
Swiss-prot Accession numberP14200 (Sequence in FASTA format)
DescriptionPro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted protein
Developmental StageExpression is strongly increased in hypothalamus between postnatal days 12 and 20, to reach high constant values in adult.
Similarity Belongs to the melanin-concentrating hormone family.
Tissue SpecificityMCH is present in all regions of the brain and in neurointermediate lobe of the pituarity gland, with highest concentrations in the hypothalamus. Also expressed to a much lesser extent in stomach, lamina propria of both duodenum and colon, ovary, thymus, pancreas, adrenal gland and testis (spermatogonia, early spermatocytes and Sertoli cells). Weak expression in heart and lung. The other peptides are expressed at least in Sertoli cells, nei being also expressed in brain, stomach and proximal duodenum. In brain exclusively mature mch and nei peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. At low levels fully processed MCH and NEI peptides are present in gut. No expression in peripheral blood
Post translational modification Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide.
Function NEI can influence differentiation of neuronal processes in brain neurons. Affects the content of neurofilament protein in neuritogenesis (in vitro). May also be a neuromodulatory factor. In behavioral tests, it stimulates exploration and anxiety when injected into the ventromedial nucleus. Also stimulates grooming, locomotion and rearing. May antagonize the inhibitory effect of mch on ACTH release. Reduces dopamine and dopac release in the ventromedial nucleus
Protein Length165 Amino acids
Molecular weight18482
References1  PubMed abstract 2477226
2  PubMed abstract 2261081
3  PubMed abstract 2759038
4  PubMed abstract 7783849
5  PubMed abstract 8593803
6  PubMed abstract 7617126
7  PubMed abstract 1327720
8  PubMed abstract 10037747
9  PubMed abstract 7647772
10  PubMed abstract 9700748
11  PubMed abstract 9809645
Domain NamePro-MCH  
Hormone NameNeuropeptide-glutamic acid-isoleucine
Mature Hormone SequenceEIGDEENSAKFPI
Position of mature hormone in Pre-Hormone protein13 Residues from position (131-143)
ReceptorP97639    Detail in HMRbase   
Gene ID24659      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 2

HMRbase accession number11410
Swiss-prot Accession numberP14200 (Sequence in FASTA format)
DescriptionPro-MCH precursor [Contains: Neuropeptide-glycine-glutamic acid (NGE)(Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine (NEI)(Neuropeptide E-I); Melanin-concentrating hormone (MCH)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted protein
Developmental StageExpression is strongly increased in hypothalamus between postnatal days 12 and 20, to reach high constant values in adult.
Similarity Belongs to the melanin-concentrating hormone family.
Tissue SpecificityMCH is present in all regions of the brain and in neurointermediate lobe of the pituarity gland, with highest concentrations in the hypothalamus. Also expressed to a much lesser extent in stomach, lamina propria of both duodenum and colon, ovary, thymus, pancreas, adrenal gland and testis (spermatogonia, early spermatocytes and Sertoli cells). Weak expression in heart and lung. The other peptides are expressed at least in Sertoli cells, nei being also expressed in brain, stomach and proximal duodenum. In brain exclusively mature mch and nei peptides are present. In peripheral tissues a large product, encompassing the NEI and MCH domains of the precursor, is found predominantly. At low levels fully processed MCH and NEI peptides are present in gut. No expression in peripheral blood
Post translational modification Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. MCH is a cyclic peptide.
Function MCH inhibits ACTH secretion at the end of the light on period which corresponds to the peak of the circadian rhythm in ACTH. Inhibits also stress induced ACTH release during the light off period of the cycle. Involved as a neurotransmitter or neuromodulator in a broad array of neuronal functions. Stimulates sexual behavior when injected into the ventromedial nucleus, this effect is antagonized by NEI. In the medial preoptic area, stimulates anxiety and sexual behavior. Antagonizes inhibitory effect of melanotropin alpha on exploration behavior
Protein Length165 Amino acids
Molecular weight18482
References1  PubMed abstract 2477226
2  PubMed abstract 2261081
3  PubMed abstract 2759038
4  PubMed abstract 7783849
5  PubMed abstract 8593803
6  PubMed abstract 7617126
7  PubMed abstract 1327720
8  PubMed abstract 10037747
9  PubMed abstract 7647772
10  PubMed abstract 9700748
11  PubMed abstract 9809645
Domain NamePro-MCH  
Hormone NameMelanin-concentrating hormone
Mature Hormone SequenceDFDMLRCMLGRVYRPCWQV
Position of mature hormone in Pre-Hormone protein19 Residues from position (147-165)
ReceptorP97639    Detail in HMRbase   
Gene ID24659      
PDB IDN/A
Drugpediawiki
Comments