A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21300 |
| Swiss-prot Accession number | P06537 (Sequence in FASTA format) |
| Description | RecName: Glucocorticoid receptor;GR;Alternative Name: Nuclear receptor subfamily 3 group C member 1; |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding. The hormone- occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. Sumoylated; this reduces transcription transactivation (By similarity). Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling. |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). |
| Protein Length | 783 Amino acids |
| Molecular weight | 86053 |
| Domain Name | GCR Hormone_recep zf-C4 |
| References | 1 PubMed abstract 3780669 2 PubMed abstract 2911477 3 PubMed abstract 2702670 4 PubMed abstract 2019585 5 PubMed abstract 9528750 6 PubMed abstract 9742105 7 PubMed abstract 10848625 8 PubMed abstract 10678832 9 PubMed abstract 11278753 10 PubMed abstract 11555652 11 PubMed abstract 11435610 12 PubMed abstract 11751894 13 PubMed abstract 12949501 14 PubMed abstract 15037546 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |