A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21306 |
| Swiss-prot Accession number | P06536 (Sequence in FASTA format) |
| Description | RecName: Glucocorticoid receptor;GR;Alternative Name: Nuclear receptor subfamily 3 group C member 1; |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Increased proteasome-mediated degradation in response to glucocorticoids. Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. Sumoylated; this reduces transcription transactivation (By similarity). Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). |
| Protein Length | 795 Amino acids |
| Molecular weight | 87556 |
| Domain Name | GCR Hormone_recep zf-C4 |
| References | 1 PubMed abstract 3755378 2 PubMed abstract 3684608 3 PubMed abstract 3191912 4 PubMed abstract 3216865 5 PubMed abstract 1939229 6 PubMed abstract 8450530 7 PubMed abstract 8191545 8 PubMed abstract 8618925 9 PubMed abstract 9111344 10 PubMed abstract 9603939 11 PubMed abstract 10364267 12 PubMed abstract 10480874 13 PubMed abstract 10866662 14 PubMed abstract 11278286 15 PubMed abstract 11435610 16 PubMed abstract 12118039 17 PubMed abstract 12917342 18 PubMed abstract 1865905 19 PubMed abstract 2115209 20 PubMed abstract 1751485 21 PubMed abstract 1936288 22 PubMed abstract 8257681 23 PubMed abstract 8493115 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 24413 |
| PDB ID | 1GDC 1GLU 1LAT 1R4O 1R4R 1RGD 2GDA |
| Drugpedia | wiki |
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