A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 20979 |
| Swiss-prot Accession number | P06213 (Sequence in FASTA format) |
| Description | Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta]. |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. |
| Tissue Specificity | Isoform Long and isoform Short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin. Isoform Short is expressed also in the spleen and lymphoblasts. |
| Post translational modification | After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane. Autophosphorylated on tyrosine residues in response to insulin. Phosphorylation of Tyr-999 is required for IRS1- and SHC1- binding. |
| Function | This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. |
| Protein Length | 1382 Amino acids |
| Molecular weight | 156307 |
| Domain Name | Pkinase_Tyr Recep_L_domain Furin-like Pkinase |
| References | 1 PubMed abstract 2859121 2 PubMed abstract 2983222 3 Chen E.Y.; Submitted (JUL-1985) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 2210055 5 PubMed abstract 3447155 6 PubMed abstract 2211730 7 PubMed abstract 3680248 8 PubMed abstract 2777789 9 PubMed abstract 2806055 10 PubMed abstract 2280779 11 PubMed abstract 2538124 12 PubMed abstract 2369896 13 PubMed abstract 2566545 14 PubMed abstract 3166375 15 PubMed abstract 2544997 16 PubMed abstract 1472036 17 PubMed abstract 1321605 18 PubMed abstract 2842060 19 PubMed abstract 3101064 20 PubMed abstract 8276809 21 PubMed abstract 7559478 22 PubMed abstract 7537849 23 PubMed abstract 11374898 24 PubMed abstract 16127460 25 PubMed abstract 15951569 26 PubMed abstract 7997262 27 PubMed abstract 9312016 28 PubMed abstract 14690593 29 PubMed abstract 3283938 30 PubMed abstract 2834824 31 PubMed abstract 2479553 32 PubMed abstract 2544998 33 PubMed abstract 2168397 34 PubMed abstract 2121734 35 PubMed abstract 2365819 36 PubMed abstract 1963473 37 PubMed abstract 2040394 38 PubMed abstract 2002058 39 PubMed abstract 1890161 40 PubMed abstract 1607067 41 PubMed abstract 1607076 42 PubMed abstract 1563582 43 PubMed abstract 1730625 44 PubMed abstract 1470163 45 PubMed abstract 8432414 46 PubMed abstract 8243830 47 PubMed abstract 8458533 48 PubMed abstract 8390949 49 PubMed abstract 8242067 50 PubMed abstract 8096518 51 PubMed abstract 8388389 52 PubMed abstract 8326490 53 PubMed abstract 8419945 54 PubMed abstract 8288049 55 PubMed abstract 8314008 56 PubMed abstract 8082780 57 PubMed abstract 8188715 58 PubMed abstract 7983039 59 PubMed abstract 7815442 60 PubMed abstract 7657032 61 PubMed abstract 7538143 62 PubMed abstract 8890729 63 PubMed abstract 8636294 64 PubMed abstract 9199575 65 PubMed abstract 9175790 66 PubMed abstract 9299395 67 PubMed abstract 9249867 68 ; Desbois-Mouthon C., Girodon E., Ghanem N., Caron M., Pennerath A.,Conteville P., Magre J., Besmond C., Goossens M., Capeau J.,Amselem S.; "Molecular analysis of the insulin receptor gene for prenataldiagnosis of leprechaunism in two families."; Prenat. Diagn. 17:657-663(1997). 69 PubMed abstract 9703342 70 PubMed abstract 10443650 71 PubMed abstract 10733238 72 PubMed abstract 11260230 73 PubMed abstract 12107746 74 PubMed abstract 12023989 75 PubMed abstract 12538626 76 PubMed abstract 12970295 77 PubMed abstract 15161766 78 PubMed abstract 17201797 |
| Hormone | P01308 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | 1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 |
| Drugpedia | wiki |
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