A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21256 |
| Swiss-prot Accession number | P03372 (Sequence in FASTA format) |
| Description | RecName: Estrogen receptor;ER;Alternative Name: Estradiol receptor;Alternative Name: ER-alpha;Alternative Name: Nuclear receptor subfamily 3 group A member 1; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity. Glycosylated; contains N-acetylglucosamine, probably O- linked. |
| Function | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. |
| Protein Length | 595 Amino acids |
| Molecular weight | 66216 |
| Domain Name | Hormone_recep Oest_recep zf-C4 |
| References | 1 PubMed abstract 3753802 2 PubMed abstract 3754034 3 PubMed abstract 8600466 4 PubMed abstract 14574404 5 PubMed abstract 10619354 6 PubMed abstract 7916651 7 PubMed abstract 7476978 8 PubMed abstract 7539106 9 PubMed abstract 1577818 10 PubMed abstract 7838153 11 PubMed abstract 8999954 12 PubMed abstract 9627117 13 PubMed abstract 10428798 14 PubMed abstract 10567404 15 PubMed abstract 10359819 16 PubMed abstract 10825160 17 PubMed abstract 11358960 18 PubMed abstract 11113208 19 PubMed abstract 11971969 20 PubMed abstract 12415108 21 PubMed abstract 12917342 22 PubMed abstract 15047147 23 PubMed abstract 15199063 24 PubMed abstract 15940264 25 PubMed abstract 16603732 26 PubMed abstract 16427018 27 PubMed abstract 17658481 28 PubMed abstract 17347654 29 PubMed abstract 17998543 30 PubMed abstract 18187866 31 PubMed abstract 2247153 32 PubMed abstract 8221895 33 PubMed abstract 9338790 34 PubMed abstract 9600906 35 PubMed abstract 9875847 36 PubMed abstract 9619507 37 PubMed abstract 2792078 38 PubMed abstract 8961262 39 PubMed abstract 9195227 40 PubMed abstract 10942433 41 PubMed abstract 17224074 |
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| Gene ID | 2099 |
| PDB ID | 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW |
| Drugpedia | wiki |
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