A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11328 |
| Swiss-prot Accession number | P01270 (Sequence in FASTA format) |
| Description | Parathyroid hormone precursor (Parathyrin) (PTH) (Parathormone). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Secreted protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the parathyroid hormone family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion |
| Protein Length | 115 Amino acids |
| Molecular weight | 12861 |
| References | 1 PubMed abstract 6950381 2 PubMed abstract 6220408 3 PubMed abstract 15489334 4 PubMed abstract 4833516 5 PubMed abstract 15340161 6 PubMed abstract 4521809 7 PubMed abstract 728431 8 Keutmann H.T., Niall H.D., Jacobs J.W., Barling P.M., Hendy G.N.,O'Riordan J.L.H., Potts J.T. Jr.; (In) Talmadge R.V., Owen M., Parsons J.A. (eds.);Calcium-regulating hormones, pp.9-14, Excerpta Medica Foundation,Amsterdam (1975). 9 PubMed abstract 1125201 10 PubMed abstract 4474131 11 PubMed abstract 4721748 12 PubMed abstract 2069952 13 PubMed abstract 8344299 14 PubMed abstract 7797503 15 PubMed abstract 10623601 16 PubMed abstract 2212001 17 PubMed abstract 10523031 |
| Domain Name | Parathyroid |
| Hormone Name | Parathyroid hormone (Parathyrin) (PTH) |
| Mature Hormone Sequence | SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ |
| Position of mature hormone in Pre-Hormone protein | 84 Residues from position (32-115) |
| Receptor | Q03431
Detail in HMRbase |
| Gene ID | 5741 |
| PDB ID | 1BWX 1ET1 1ET2 1FVY 1HPH 1HPY 1HTH 1ZWA 1ZWB 1ZWD 1ZWE 1ZWF 1ZWG |
| Drugpedia | wiki |
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