A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 22992 |
| Swiss-prot Accession number | O75787 (Sequence in FASTA format) |
| Description | Renin receptor;Alternative Name: Renin/prorenin receptor;Alternative Name: ATPase H(+)-transporting lysosomal accessory protein 2;Alternative Name: ATPase H(+)-transporting lysosomal-interacting protein 2;Alternative Name: Vacuolar ATP synthase membrane sector-associated protein M8-9;Short=V-ATPase M8.9 subunit;Alternative Name: ATP6M8-9;Alternative Name: N14F;Alternative Name: ER-localized type I transmembrane adaptor;Alternative Name: Embryonic liver differentiation factor 10;Precursor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; Single-pass type I membrane protein (Potential) |
| Developmental Stage | N/A |
| Similarity | N/A |
| Tissue Specificity | Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncitiotrophoblast cells in the mature fetal placenta. |
| Post translational modification | Phosphorylated. |
| Function | Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). |
| Protein Length | 350 Amino acids |
| Molecular weight | 39008 |
| Domain Name | Renin_r |
| References | 1 PubMed abstract 12045255 2 PubMed abstract 10931946 3 PubMed abstract 15489334 4 PubMed abstract 9556572 5 PubMed abstract 15746149 |
| Hormone | P00797 Detail in HMRbase Q6FI38 Detail in HMRbase |
| Gene ID | 10159 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |