| HMRbase accession number | 20976 |
| Swiss-prot Accession number | O46600 (Sequence in FASTA format) |
| Description | Growth hormone receptor precursor (GH receptor) (Somatotropinreceptor) [Contains: Growth hormone-binding protein (GH-bindingprotein) (GHBP) (Serum-binding protein)]. |
| Source organism | Bos taurus (Bovine) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Bovinae; Bos. |
| Subcellular location | Cell membrane; single-pass type I membrane protein (By similarity). Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain. |
| Tissue Specificity | Highly expressed in both adult and fetal liver. Lower levels in kidney, anterior pituitary, skeletal muscle, adipose tissue and mammary gland. |
| Post translational modification | On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (By similarity). On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity). |
| Function | Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. |
| Protein Length | 634 Amino acids |
| Molecular weight | 70901 |
| Domain Name | N/A |
| References | 1 PubMed abstract 2289631
2 PubMed abstract 9710756
3 Zhou Y., Jiang H.; "Functional expression of bovine growth hormone receptor."; Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
4 PubMed abstract 11255006
5 PubMed abstract 10376317
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| Hormone | P01246 Detail in HMRbase
|
| Gene ID | 280805 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors