A database of hormones and their receptors
Receptor

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HMRbase accession number21309
Swiss-prot Accession numberO46567 (Sequence in FASTA format)
DescriptionRecName: Glucocorticoid receptor;GR;Alternative Name: Nuclear receptor subfamily 3 group C member 1;
Source organismSaimiri sciureus (Common squirrel monkey)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Platyrrhini; Cebidae; Saimiriinae; Saimiri.
Subcellular locationCytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (By similarity)
Developmental StageN/A
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue SpecificityExpressed in brain. Regions of high expression include CA1 and CA2 of hippocampus, dentate gyrus, paraventricular hypothalamus, lateral geniculate, lateral-medial amygdala, and cerebellum. In the cerebral cortex, laminar patterns of expression were apparent in all cortical layers, particularly the pyramidal cell-rich layers II/III and V.
Post translational modification Increased proteasome-mediated degradation in response to glucocorticoids (By similarity). Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids (By similarity). Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). Sumoylated; this reduces transcription transactivation (By similarity).
Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling (By similarity). Plays a significant role in transactivation. Involved in nuclear translocation.
Protein Length778 Amino acids
Molecular weight85738
Domain NameGCR  Hormone_recep  zf-C4  
References1  PubMed abstract 10775802
2  PubMed abstract 11703081
3  PubMed abstract 11165305
4  PubMed abstract 15857751
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Gene IDN/A
PDB IDN/A
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